38th Symposium of Veterinary Medicine in honor of Prof. Uri Bar-Gai. In: Israel Journal of Veterinary Medicine - Vol. 71 - N°1 - Mar. 2016

S: SMALL ANIMALS AND WILD ANIMALS The Effect of Naturally Occurring Chronic Kidney Disease on the Micro-Structural and Mechanical Properties of Bone in Dogs Shipov, A., Shahar, R., Sugark N. and Segev, G. Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel. Chronic kidney disease (CKD) is common in dogs. One of its inevitable consequences is secondary renal hyperparathyroidism, resulting in persistently high parathyroid hormone (PTH) concentration, which promotes bone resorption by activating osteoclasts in presence of osteoblasts. In humans, bone resorption, osteopenia, and increased risk of fractures are well documented, but the effect of CKD on bone quality has not been studied in dogs. The aim of this study was to investigate the effect of naturally occurring CKD on bone morphometry and mechanical properties. Femora of nine dogs with CKD and nine age, sex and body weight matched dogs were harvested after death or euthanasia. Morphometric properties were assessed using light microscopy and Micro CT. Young’s modulus was assessed using the 4-point bending test. Lacunae were significantly smaller in the CKD group, with no group difference in Haversian canal and resorption cavity size. Resorption cavity density [10 (8-14) vs. 7 (4-9) mm-2 in the CKD and control, respectively, P= 0.001] and overall porosity (2.3-fold higher in the CKD) were significantly higher in the CKD group. There was no group difference in Young’s moduli. In conclusion, CKD in dogs is associated with deterioration in bone quality, which is not manifested clinically. Therapeutic Soft Contact Lenses May Alter the Efficacy of Topically Administered Ocular Drugs Hatzav, M., Bdolah-Abram, T. and Ofri, R. Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel. Therapeutic soft contact lenses (TSCLs) are often used in veterinary medicine to protect and support the cornea in cases of corneal trauma and disease. However, TSCLs are usually used as adjunct therapy, and are not meant to replace medical treatment, as the diseased eyes still need to be medicated topically. Yet the effectiveness of topical ophthalmic medications administered to a TSCL-covered eye, rather than directly to the bare eye, has never been studied. This led us to examine the efficacy of two topical ocular drugs with a quantifiable effect, 0.5% tropicamide (mydramide) and 0.005% latanoprost (glautan), in TSCLs covered and uncovered eyes of six Labrador retriever dogs. Pupil diameter (PD) and intra-ocular pressure (IOP) values were measured at time 0 and later hourly for 8 h, and the mydriasis or intraocular hypotension caused by tropicamide and 38th Symposium of Veterinary Medicine March 2016.indb 63 17/03/2016 11:04:26 Published in IVIS with the permission of the editor Close window to return to IVIS